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The Marine Mammal Center Responds to Second Largest Leptospirosis Outbreak on Record – More than 220 Sea Lions Impacted

More than half of the California sea lions rescued this year have been suffering from effects of the bacteria that can cause fatal kidney damage.


October 16, 2018

California sea lion Johnny. Photo by Bill Hunnewell © The Marine Mammal Center


Over the course of 2018, more than 220 California sea lions rescued by The Marine Mammal Center have been diagnosed with leptospirosis, a potentially fatal bacterial infection. That means we're in the middle of the second largest leptospirosis outbreak on record here at the Center.

During the last major outbreak in 2011, nearly 200 infected sea lion patients were admitted to our hospital. Based on historical data, we know that the majority of leptospirosis cases occur between July and November, peaking in August-September. So we expect to continue to see cases for the next few months.

Of the more than 10,000 calls The Marine Mammal Center’s Rescue Hotline receives every year, some are more routine than others. And during a major leptospirosis outbreak like the one the Center is facing right now, a lot of those calls sound very similar to the ones our rescue team received about Grazer.

California sea lion Grazer at the time of his rescue. Photo © The Marine Mammal Center


Grazer was spotted on a beach in Monterey near the entrance to some condos. He was curled up by the sea wall with his flippers folded tightly over his abdomen, like a small child with a stomachache. That posture caused by abdominal pain and general malaise, sometimes called the “lepto pose,” is a classic sign the sea lion is suffering from the effects of a spiral-shaped bacteria called Leptospira.

The bacterial infection affects the kidneys and can be lethal if not treated. Another classic sign of the infection in sea lions is the desire to drink water. Marine mammals generally do not need to drink water because they receive all the hydration they need from food sources. But when they are infected with Leptospira, their kidneys stop functioning properly and cannot filter toxins or regulate hydration.

Leptospirosis is a major health burden for humans, domestic animals and wildlife worldwide with over 500,000 severe cases in humans every year. Leptospira can cause disease ranging from infection with no symptoms to severe and possibly fatal disease.

The type of Leptospira affecting California sea lions at The Marine Mammal Center is a strain that has also been associated with pigs, skunks and foxes. It’s transmitted via urine, either directly or via contaminated water or soil.

Researchers haven’t definitively determined how transmission occurs within the sea lion population, but they believe it occurs primarily while sea lions are hauled out on land. The bacteria may also survive for short periods in seawater, so transmission may be possible when large groups of sea lions gather in the water.

Sea lions diagnosed with leptospirosis are treated with antibiotics, fluids and other supportive care, such as gastroprotectants for stomach and intestinal ulcers. Unfortunately, even with treatment, roughly two-thirds of the animals that strand with acute leptospirosis do not survive.

However, research using data and samples collected at The Marine Mammal Center, as well as data collected from sea lions in the wild, indicates that many sea lions infected with Leptospira survive and likely experience mild or no symptoms of the disease, unlike in the acute cases seen at our hospital.

When a leptospirosis outbreak occurs, our scientists study the disease to learn more about what causes an outbreak and how we can improve treatment for infected animals. Thanks to the Center’s 43 years of stranding records and bank of blood and urine samples, researchers have a unique opportunity to investigate the disease patterns over four decades.

“We learn from every single patient we admit here at the Center,” says Dr. Shawn Johnson, Director of Veterinary Science at The Marine Mammal Center. “But it’s our long history of rehabilitation and our commitment to scientific research that allows us to see bigger picture impacts on the ocean environment.”

California sea lion Zoltan. Photo by Bill Hunnewell © The Marine Mammal Center


For over 10 years, scientists at The Marine Mammal Center have collaborated with researchers at the Lloyd-Smith Laboratory in the Department of Ecology and Evolutionary Biology at UCLA to study the dynamics of this pathogen in the California sea lion population. The Center has been at the forefront of research on leptospirosis in marine mammals and has published a number of scientific papers on the disease dating back to 1985.

Leptospira was first detected in California sea lions in 1970 during a leptospirosis outbreak that occurred along the coast of California, Oregon and Washington. And since the 1980s, we have seen yearly, seasonal outbreaks with major outbreak events causing 100 or more sea lion strandings happening every four to five years.

The reasons for these periodic major outbreaks in sea lions is unknown, however our UCLA collaborators believe that a combination of factors may be responsible, such as changes in herd immunity, sea surface temperatures and sea lion migration patterns.

Interestingly, after 30 uninterrupted years of seeing at least a few cases of leptospirosis annually, the disease disappeared from the population in late 2013 only to reappear four years later.

“Thanks to our long-term collaboration with The Marine Mammal Center, we have an opportunity to investigate this highly unique situation during which a continuously circulating pathogen disappears from a wildlife host for a number of years and then reemerges,” says Dr. Katie Prager, a veterinarian and researcher from the Lloyd-Smith Laboratory. “This is a fascinating case study that we can use to learn more about infectious disease ecology and how outbreaks are impacted by environmental changes.”

Dr. Prager and her colleagues at UCLA believe the disappearance of the disease may be related to the highly anomalous oceanographic conditions that occurred during the same time period. The abnormally warm waters, commonly referred to as “the Blob,” may have caused changes in sea lion behavior and migration patterns as they struggled to find food sources.

This period of dramatic, out-of-the-ordinary ocean conditions has been described as a “climate change stress test” due to its unprecedented duration and intensity and such events are projected to become more common under future global change scenarios.

California sea lions Princepajaro and Maeley. Photo by Bill Hunnewell © The Marine Mammal Center


You may recall that these abnormal oceanographic conditions led to a large-scale stranding event in 2013-2017—what we dubbed the “sea lion tsunami”—in which we rescued unprecedented numbers of starving young sea lions. All told, thousands of sea lions stranded along the California coast during this multi-year period of warmer waters. Although oceanographic conditions have normalized in recent years, the impacts of this catastrophic event are still being felt in many ways.

“As climate change continues to wreak havoc on ocean health, causing more and more situations like we saw with ‘the Blob,’ it’s vital that we study the potential long-term implications of future environmental disturbances on ecosystem health and related issues, like infectious disease,” Dr. Johnson says.

Over the course of the next month, the Center’s biologists and veterinary staff will be working with Dr. Prager to take blood and urine samples from wild juvenile California sea lions at Año Nuevo Island. This popular haulout site located about a mile offshore is utilized by young California sea lions foraging for food after the summer breeding season.

The blood samples will tell researchers whether the sea lions have evidence of kidney disease and whether they are carrying antibodies that indicate past exposure to Leptospira while the urine samples can be tested for current infection. Once the samples are collected, the animals are tagged and released.

This collaborative research project also relies on long-term demographic datasets generated by our partners at the NOAA Fisheries Marine Mammal Laboratory. These biologists monitor and track pups born on the Channel Islands every year. We also work closely with biologists in Oregon and Washington who monitor the sea lions in those areas, and they’ve been reporting suspected cases of leptospirosis in recent months as well.

Many different animal species, including humans and dogs, can become infected with Leptospira through contact with contaminated urine, water or soil. The Marine Mammal Center has a number of safety protocols in place to prevent transmission to veterinarians and volunteers working with our sea lion patients.

How the Public Can Help:

  • Report sick marine mammals to The Marine Mammal Center by calling our 24-hour hotline at 415-289-SEAL(7325).
  • Maintain a safe distance of at least 50 feet and keep dogs away.
  • Support this life-saving work by making a gift today.


Leptospirosis Research at The Marine Mammal Center

Over the last 40 years, our veterinarians and scientists have contributed to a number of scientific papers on leptospirosis, some of which can be viewed here:

Buhnerkempe, M.G., Prager, K.C., Strelioff, C.C., Greig, D.J., Laake, J.L., Melin, S.R., DeLong, R.L., Gulland, F.M.D., Lloyd-Smith, J.O. 2017. Detecting signals of chronic shedding to explain pathogen persistence: Leptospira interrogans in California sea lions. Journal of Animal Ecology. 86: 460-472.

Prager, K.C., Alt, D. P., Buhnerkempe, M.G., Greig, D.J., Galloway, R.L., Wu, Q., Gulland, F.M.D., Lloyd-Smith, J.O. 2015. Antibiotic efficacy in eliminating leptospiruria in California sea lions (Zalophus californianus) stranding with leptospirosis. Aquatic Mammals 41(2): 203-212.

Prager, K.C., Greig, D.J., Alt, D.P., Galloway, R.L., Hornsby, R.L., Palmer, L.J., Soper, J., Wu, Q., Zuerner, R.L., Gulland, F.M.D., Lloyd-Smith, J.O. 2013. Asymptomatic and chronic carriage of Leptospira interrogans serovar Pomona in California sea lions (Zalophus californianus). 164 (2013): 177-183.

Zuerner, R.L, Cameron, C.E., Raverty, S., Robinson, J., Colegrove, K.M., Norman, S.A., Lambourn, D., Jefferies, S., Alt, D.P. and Gulland, F. 2009. Geographical dissemination of Leptospiria interrogans serovar Pomona during seasonal migration of California sea lions. Veterinary Microbiology. 137: 105-110.

Cameron, C.E., Zuerner, R.L., Raverty, S., Colegrove, K.M., Norman, S.A., Lambourn, D.M., Jeffries, S.J., and Gulland, F.M. 2008. Detection of pathogenic Leptospira bacteria in pinniped populations via PCR and identification of a source of transmission for zoonotic leptospirosis in the marine environment. Journal of Clinical Microbiology, 46(5): 1728-1733.

Norman, S.A., DiGiacomo, R.F., Gulland, F.M.D., Meschke, J.S., and Lowry, M.S. 2008. Risk factors for an outbreak of leptospirosis in California sea lions (Zalophus californianus) in California, 2004. Journal of Wildlife Diseases, 44(4): 837-844.

Lloyd-Smith, J.O., Greig, D.J., Hietala, S., Ghneim, G.S., Palmer, L., St. Leger, J., Grenfell, B.T., and Gulland, F.M.D. 2007. Cyclical changes in seroprevalence of leptospirosis in California sea lions: endemic and epidemic disease in one host species? BioMed Central Infectious Disease 7: 125.

 


 

  


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Related:

Learn about: California sea lions

Learn more about Leptospirosis

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