Diagnostic Tests for Lungworm-Infected Northern Elephant Seals
- Lungworm
- Parasites
- Medicine
- Diagnostics
Abstract
The nematode lungworm, Otostrongylus circumlitis (OC), is a significant cause of northern elephant seal (NES; Mirounga angustirostris) mortality at The Marine Mammal Center (TMMC, Sausalito, CA). The current lack of specific antemortem diagnostic tests for pre-patent OC infection in NES makes diagnosis, proper treatment, and assessment of efficacy of medications challenging. Severe inflammation and disseminated intravascular coagulation (DIC) develop rapidly and are difficult to treat once clinical signs develop. Certain blood inflammatory and hemostasis biomarkers for early diagnosis have recently been investigated. The objective of this study was to investigate the diagnostic performance of complete blood count, serum chemistry, acute phase proteins, protein electrophoresis, and coagulation parameters for diagnosis of OC clinical infection in NES. Samples from NES with OC infection confirmed by gross pathology with blood collected antemortem during clinical disease (n = 9) and NES initially admitted for malnutrition and sampled shortly before release after successful rehabilitation (n = 20) were included in the study. Using Receiver operator characteristic (ROC) curve analysis, the diagnostic performances (area under the curve [AUC]) of albumin (0.994), albumin:globulin ratio (0.983), serum amyloid A (0.972), activated partial thromboplastin time (0.936), total bilirubin (0.975), and gamma-glutamyl transferase (0.939) were high (AUC > 0.9). These results confirm systemic inflammation and DIC, and support previously reported clinical and gross pathological findings in NES infected with OC. In addition to AUC values, this study produced cut-off points, sensitivity, specificity, confidence intervals, and predictive values for analytes with high diagnostic performance. This data will be useful in the diagnosis and clinical management of OC-infected NES and will aid in assessment of treatment efficacy.
Julie D. Sheldon, Jorge A. Hernandez, Shawn P. Johnson, Cara Field, Sarrah Kaye and Nicole I. Stacy. Diagnostic Performance of Clinicopathological Analytes in Otostrongylus circumlitis-Infected Rehabilitating Juvenile Northern Elephant Seals (Mirounga angustirostris). Frontiers in Veterinary Science, 25 April 2019.
parasites
medicine
diagnostics
Cara Field
Meet The Experts
{"image":"\/People\/Portrait\/cara-field.jpg","alt":"Cara Field","title":"Cara Field","text":"Medical Director","link_url":"https:\/\/www.marinemammalcenter.org\/person\/cara-field","link_text":"Read Bio"}
Related Publications
{"image":"\/Animals\/Patients\/California sea lions\/csl-by-bill-hunnewell-c-the-marine-mammal-center-1.jpg","alt":"California sea lion eating a fish","title":"New Technique for Diagnosing Lung Parasite Infections in Sea Lions","link_url":"https:\/\/www.marinemammalcenter.org\/publications\/new-technique-for-diagnosing-lung-parasite-infections-in-sea-lions","label":"Research Paper"}
{"image":"\/Animals\/Wild\/Humpback whale\/cropped-images\/humpback-whale-sea-lions-photo-c-bill-hunnewell-190-2-2774-2167-1659123832.jpg","alt":"humpback whales and California sea lions feeding","title":"Aquatic Mammals","link_url":"https:\/\/www.marinemammalcenter.org\/publications\/aquatic-mammals","label":"Research Paper"}
{"image":"\/Animals\/Patients\/Guadalupe fur seals\/2021\/cropped-images\/gfs-skyrocket-by-bill-hunnewell-c-the-marine-mammal-center-noaa-permit-18786-2-112-1667-1302-1625765450.jpg","alt":"Guadalupe fur seal Skyrocket","title":"Vasculitis and Thrombosis due to the Sea Lion Lungworm in a Guadalupe Fur Seal","link_url":"https:\/\/www.marinemammalcenter.org\/publications\/vasculitis-and-thrombosis-due-to-the-sea-lion-lungworm-in-a-guadalupe-fur-seal","label":"Research Paper"}
Vasculitis and Thrombosis due to the Sea Lion Lungworm in a Guadalupe Fur Seal
Read More{"image":"\/Animals\/Patients\/Elephant seals\/2021\/cropped-images\/es-mizuna-by-bill-hunnewell-c-the-marine-mammal-center-5-70-2542-1985-1626807943.jpeg","alt":"northern elephant seal Mizuna","title":"Acute-Phase Responses in Healthy, Malnourished and Lungworm-Infected Juvenile Northern Elephant Seals","link_url":"https:\/\/www.marinemammalcenter.org\/publications\/acute-phase-responses-in-healthy-malnourished-and-lungworm-infected-juvenile-northern-elephant-seals","label":"Research Paper"}
Acute-Phase Responses in Healthy, Malnourished and Lungworm-Infected Juvenile Northern Elephant Seals
Read MoreRecent News
{"image":"\/Animals\/Wild\/California sea lion\/cropped-images\/csl-release-4-5-24photo-by-chris-deimler-c-the-marine-mammal-center-138-0-1270-992-1745348188.jpg","alt":"Four young California sea lions walk on the beach toward the ocean.","title":"Achievements in Ocean Health","link_url":"https:\/\/www.marinemammalcenter.org\/news\/achievements-in-ocean-health","label":"News Update","date":"2025-04-23 10:20:00"}
{"image":"\/Misc\/Graphics\/cropped-images\/climate-change-graphic-giant-earth-shutterstock-1798-6-5113-3994-1680046432.jpg","alt":"An Earth Day graphic of people holding the planet, recycling, planting a tree and moving a solar panel.","title":"5 Ways to Celebrate Earth Day","link_url":"https:\/\/www.marinemammalcenter.org\/news\/5-ways-to-celebrate-earth-day","label":"News Update","date":"2025-04-18 11:21:08"}
{"image":"\/Animals\/Wild\/Sea otter\/cropped-images\/sea-otter-mom-pup-photo-c-brian-simuro-505-0-3387-2646-1618247266.jpg","alt":"sea otter mother and pup","title":"Meaningful Mother\u2019s Day Gifts for Ocean Lovers","link_url":"https:\/\/www.marinemammalcenter.org\/news\/eco-friendly-mothers-day-gifts-that-give-back","label":"News Update","date":"2025-04-10 02:00:00"}
{"image":"\/Animals\/Wild\/Harbor seal\/cropped-images\/harbor-seals-shutterstock-107-0-1270-992-1744225508.jpg","alt":"A group of harbor seal pups and mothers on the beach during pupping season.","title":"Your Guide to Seeing Harbor Seal Pups in California","link_url":"https:\/\/www.marinemammalcenter.org\/news\/your-guide-to-seeing-harbor-seal-pups-in-california","label":"News Update","date":"2025-04-10 00:00:00"}
